Zegalogue® (dasiglucagon) injection 0.6 mg/0.6 mL Zegalogue® (dasiglucagon) injection 0.6 mg/0.6 mL

Treating low blood sugar is an important part of living with diabetes

People with diabetes taking insulin are at risk for very low blood sugar

The focus of diabetes management is to lower your blood sugar levels with insulin. However, there is a risk of blood sugar dropping too low.

Low blood sugar (lower than 70 mg/dL) is called hypoglycemia. If hypoglycemia is mild or moderate, it can be treated with fast-acting carbohydrates like hard candies and juice.

Low blood sugar is considered severe (a blood sugar emergency) if you are too weak or confused to eat or drink anything and need another person to help you recover. If blood sugar drops too low, you may lose consciousness and could choke on food or liquids.

Low blood sugar can often be unpredictable

While many risk factors for low blood sugar relate to specific actions, some factors may be out of your control.

Situations that may increase the risk of low blood sugar include:

  • Delaying mealtimes or fasting
  • Taking too much insulin
  • Consuming alcohol
  • Exercising intensely
  • Sleeping, especially overnight
  • Stressful events (such as illness, trauma, or surgery) that impact glycemic control
  • Early childhood or older age

Low blood sugar can feel different for different people

Every person has different symptoms when their blood sugar drops. It’s important to know which ones you feel when your blood sugar is very low, so you and the people around you know what symptoms of very low blood sugar to look out for. 

Early symptoms of low blood sugar may include:

  • Sweating
  • Drowsiness (feeling tired)
  • Dizziness
  • Sleep disturbances
  • Irregular heartbeat (palpitation)
  • Anxiety
  • Tremor (feeling shaky)
  • Blurred vision
  • Hunger
  • Slurred speech
  • Restlessness
  • Depressed mood
  • Tingling in the hands, feet, lips, or tongue
  • Irritability
  • Abnormal behavior
  • Lightheadedness
  • Unsteady movement
  • Inability to concentrate
  • Personality changes
  • Headache

If not treated early, the symptoms of low blood sugar may worsen. Signs and consequences of very low blood sugar include:  

  • Confusion
  • Seizures
  • Unconsciousness
  • Death

Be ready when blood sugar drops without warning or symptoms

For some people living with diabetes, their blood sugar can drop dangerously low without feeling any symptoms. This is called hypoglycemia unawareness. 

If you experience very low blood sugar often, then you may develop hypoglycemia unawareness. Hypoglycemia unawareness can make it difficult to be ready for an unexpected drop in blood sugar.

It’s important that you and the people around you know what to do if very low blood sugar occurs. They may be able to help if your blood sugar drops too low without you noticing.

Up to

25%

of people living with type 1 diabetes may experience hypoglycemia unawareness

If you wear a continuous glucose monitor (CGM), you may still be at risk for very low blood sugar

When your blood sugar drops, rescue treatment can help you recover. Learn how you and those around you can be prepared for the unexpected

TREATING VERY LOW BLOOD SUGAR

Indication and Important Safety Information
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What is ZEGALOGUE®?

ZEGALOGUE® (dasiglucagon) injection is a prescription medicine used to treat very low blood sugar (severe hypoglycemia) in people with diabetes aged 6 years and older. It is not known if ZEGALOGUE® is safe and effective in children under 6 years of age.

Scroll to Indication

Important Safety Information

Do not use ZEGALOGUE® if you:

  • have a tumor called pheochromocytoma in the gland on top of your kidneys (adrenal gland).
  • have a tumor called insulinoma in your pancreas.

Before using ZEGALOGUE®, tell your healthcare provider about all of your medical conditions, including if you:

  • have a tumor in your pancreas.
  • are allergic to dasiglucagon, or any other ingredients in ZEGALOGUE®.
  • have not had food or water for a long time (prolonged fasting or starvation).
  • have adrenal insufficiency.
  • have low blood sugar that does not go away (chronic hypoglycemia).
  • are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. It is not known if ZEGALOGUE® passes into your breast milk. You and your healthcare provider should decide if you can use ZEGALOGUE® while breastfeeding.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I use ZEGALOGUE®? 

  • Read the detailed Instructions For Use that come with ZEGALOGUE®.
  • Use ZEGALOGUE® exactly how your healthcare provider tells you to use it.
  • Make sure your caregiver knows where you keep your ZEGALOGUE® and how to use ZEGALOGUE® the right way before you need it.
  • Your caregiver must act quickly. Having very low blood sugar for a period of time may be harmful.
  • Your healthcare provider will tell you how and when to use ZEGALOGUE®.
  • After giving ZEGALOGUE® your caregiver should call for emergency medical help right away.
  • Once you are able to safely consume food or drink, your caregiver should give you a fast-acting source of sugar (such as fruit juice) and a long-acting source of sugar (such as crackers with cheese or peanut butter).
  • If you do not respond to treatment after 15 minutes, your caregiver may give you another dose, if available.
  • Tell your healthcare provider each time you use ZEGALOGUE®. Your healthcare provider may need to change the dose of your other diabetes medicines.

What are the possible side effects of ZEGALOGUE®?

ZEGALOGUE® may cause serious side effects, including:

  • high blood pressure. ZEGALOGUE® can cause high blood pressure in certain people with tumors in their adrenal glands.
  • low blood sugar. ZEGALOGUE® can cause certain people with tumors in their pancreas called insulinomas to have low blood sugar.
  • serious allergic reaction. Call your healthcare provider or get medical help right away if you have a serious allergic reaction including: rash, difficulty breathing, low blood pressure (hypotension).

The most common side effects of ZEGALOGUE® include: in adults: nausea, vomiting, headache, diarrhea, and injection site pain; in children: nausea, vomiting, headache, and injection site pain. These are not all the possible side effects of ZEGALOGUE®.

Please see ZEGALOGUE® Full Prescribing Information, including Patient Information.

Scroll to ISI

What is ZEGALOGUE®?

ZEGALOGUE® (dasiglucagon) injection is a prescription medicine used to treat very low blood sugar (severe hypoglycemia) in people with diabetes aged 6 years and older. It is not known if ZEGALOGUE® is safe and effective in children under 6 years of age.

What is ZEGALOGUE®?

ZEGALOGUE® (dasiglucagon) injection is a prescription medicine used to treat very low blood sugar (severe hypoglycemia) in people with diabetes aged 6 years and older. It is not known if ZEGALOGUE® is safe and effective in children under 6 years of age.

Important Safety Information

Do not use ZEGALOGUE® if you:

  • have a tumor called pheochromocytoma in the gland on top of your kidneys (adrenal gland).
  • have a tumor called insulinoma in your pancreas.

Before using ZEGALOGUE®, tell your healthcare provider about all of your medical conditions, including if you:

  • have a tumor in your pancreas.
  • are allergic to dasiglucagon, or any other ingredients in ZEGALOGUE®.
  • have not had food or water for a long time (prolonged fasting or starvation).
  • have adrenal insufficiency.
  • have low blood sugar that does not go away (chronic hypoglycemia).
  • are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. It is not known if ZEGALOGUE® passes into your breast milk. You and your healthcare provider should decide if you can use ZEGALOGUE® while breastfeeding.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I use ZEGALOGUE®? 

  • Read the detailed Instructions For Use that come with ZEGALOGUE®.
  • Use ZEGALOGUE® exactly how your healthcare provider tells you to use it.
  • Make sure your caregiver knows where you keep your ZEGALOGUE® and how to use ZEGALOGUE® the right way before you need it.
  • Your caregiver must act quickly. Having very low blood sugar for a period of time may be harmful.
  • Your healthcare provider will tell you how and when to use ZEGALOGUE®.
  • After giving ZEGALOGUE® your caregiver should call for emergency medical help right away.
  • Once you are able to safely consume food or drink, your caregiver should give you a fast-acting source of sugar (such as fruit juice) and a long-acting source of sugar (such as crackers with cheese or peanut butter).
  • If you do not respond to treatment after 15 minutes, your caregiver may give you another dose, if available.
  • Tell your healthcare provider each time you use ZEGALOGUE®. Your healthcare provider may need to change the dose of your other diabetes medicines.

What are the possible side effects of ZEGALOGUE®?

ZEGALOGUE® may cause serious side effects, including:

  • high blood pressure. ZEGALOGUE® can cause high blood pressure in certain people with tumors in their adrenal glands.
  • low blood sugar. ZEGALOGUE® can cause certain people with tumors in their pancreas called insulinomas to have low blood sugar.
  • serious allergic reaction. Call your healthcare provider or get medical help right away if you have a serious allergic reaction including: rash, difficulty breathing, low blood pressure (hypotension).

The most common side effects of ZEGALOGUE® include: in adults: nausea, vomiting, headache, diarrhea, and injection site pain; in children: nausea, vomiting, headache, and injection site pain. These are not all the possible side effects of ZEGALOGUE®.

Please see ZEGALOGUE® Full Prescribing Information, including Patient Information.

What is ZEGALOGUE®?

ZEGALOGUE® (dasiglucagon) injection is a prescription medicine used to treat very low blood sugar (severe hypoglycemia) in people with diabetes aged 6 years and older. It is not known if ZEGALOGUE® is safe and effective in children under 6 years of age.


Zegalogue® is a registered trademark of Novo Nordisk A/S.
Novo Nordisk is a registered trademark of Novo Nordisk A/S.
All other trademarks, registered or unregistered, are the property of their respective owners.
© 2022 Novo Nordisk   All rights reserved.   US22ZGL00010   December 2022

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