Important Safety Information

Do not use ZEGALOGUE^® if you:

• have a tumor called pheochromocytoma in the gland on top of your kidneys (adrenal gland).
• have a tumor called insulinoma in your pancreas.

Before using ZEGALOGUE^®, tell your healthcare provider about all of your medical conditions, including if you:

• have a tumor in your pancreas.
• are allergic to dasiglucagon, or any other ingredients in ZEGALOGUE^®.
• have not had food or water for a long time (prolonged fasting or starvation).
• have adrenal insufficiency.
• have low blood sugar that does not go away (chronic hypoglycemia).
• are pregnant or plan to become pregnant.
• are breastfeeding or plan to breastfeed. It is not known if ZEGALOGUE^® passes into your breast milk. You and your healthcare provider should decide if you can use ZEGALOGUE^® while breastfeeding.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I use ZEGALOGUE^®? 

• Read the detailed Instructions For Use that come with ZEGALOGUE^®.
• Use ZEGALOGUE^® exactly how your healthcare provider tells you to use it.
• Make sure your caregiver knows where you keep your ZEGALOGUE^® and how to use ZEGALOGUE^® the right way before you need it.
• Your caregiver must act quickly. Having very low blood sugar for a period of time may be harmful.
• Your healthcare provider will tell you how and when to use ZEGALOGUE^®.
• After giving ZEGALOGUE^® your caregiver should call for emergency medical help right away.
• Once you are able to safely consume food or drink, your caregiver should give you a fast-acting source of sugar (such as fruit juice) and a long-acting source of sugar (such as crackers with cheese or peanut butter).
• If you do not respond to treatment after 15 minutes, your caregiver may give you another dose, if available.
• Tell your healthcare provider each time you use ZEGALOGUE^®. Your healthcare provider may need to change the dose of your other diabetes medicines.

What are the possible side effects of ZEGALOGUE^®?

ZEGALOGUE^® may cause serious side effects, including:

• high blood pressure. ZEGALOGUE^® can cause high blood pressure in certain people with tumors in their adrenal glands.
• low blood sugar. ZEGALOGUE^® can cause certain people with tumors in their pancreas called insulinomas to have low blood sugar.
• serious allergic reaction. Call your healthcare provider or get medical help right away if you have a serious allergic reaction including: rash, difficulty breathing, low blood pressure (hypotension).

The most common side effects of ZEGALOGUE^® include: in adults: nausea, vomiting, headache, diarrhea, and injection site pain; in children: nausea, vomiting, headache, and injection site pain. These are not all the possible side effects of ZEGALOGUE^®.

Please see ZEGALOGUE^® Full Prescribing Information, including Patient Information.