About Low Blood Sugar

What is the difference between low blood sugar and very low blood sugar?

Low blood sugar (lower than 70 mg/dL), is called hypoglycemia. If hypoglycemia is mild or moderate, it can be treated with fast-acting carbohydrates like hard candies, juice, or glucose tablets. Very low blood sugar (lower than 54 mg/dL) is called severe hypoglycemia and is considered a medical emergency. It requires another person to help you recover. You may be too weak or confused to eat or drink anything and you could pass out. 

Am I at risk for very low blood sugar?

People with diabetes taking insulin are at risk for very low blood sugar.

What does low blood sugar feel like?

Every person experiences the effects of low blood sugar differently. See a list of potential symptoms here.

  • Feeling weak
  • Confusion
  • Difficulty walking or seeing clearly
  • Seizures
  • Unconsciousness
  • Death
What causes very low blood sugar?

Many risk factors are outside of your control. Here are some common situations that may increase the risk of low blood sugar: 

  • Delaying mealtimes or fasting
  • Exercising intensely
  • Consuming alcohol
  • Taking too much insulin or timing of taking insulin
  • Sleeping, especially overnight



ZEGALOGUE® is a prescription medicine used to treat very low blood sugar (severe hypoglycemia) in people with diabetes aged 6 years and older. It is not known if ZEGALOGUE® is safe and effective in children under 6 years of age.

Who should not use ZEGALOGUE®?

Do not use ZEGALOGUE® if you:

  • Have a tumor called pheochromocytoma in the gland on top of your kidneys (adrenal gland)
  • Have a tumor called insulinoma in your pancreas
How does ZEGALOGUE® work?

ZEGALOGUE® is a rescue treatment that helps people with diabetes recover from very low blood sugar when they need help from others. ZEGALOGUE® comes in an autoinjector or a prefilled syringe.

How do I use ZEGALOGUE®?
  • Read the detailed Instructions For Use that come with ZEGALOGUE®. Please see Autoinjector Instructions For Use and Prefilled Syringe Instructions For Use
  • Use ZEGALOGUE® exactly how your health care provider tells you to use it
  • Make sure your caregiver knows where you keep your ZEGALOGUE® and how to use ZEGALOGUE® the right way before you need it
  • Your caregiver must act quickly. Having very low blood sugar for a period may be harmful
  • Your health care provider will tell you how and when to use ZEGALOGUE®
  • After giving ZEGALOGUE®, your caregiver should call for emergency medical help right away
  • Once you can safely consume food or drink, your caregiver should give you a fast-acting source of sugar (such as fruit juice) and a long-acting source of sugar (such as crackers with cheese or peanut butter)
  • If you do not respond to treatment after 15 minutes, your caregiver may give you another dose, if available
  • Tell your health care provider each time you use ZEGALOGUE®. Your health care provider may need to change the dose of your other diabetes medicines
How was ZEGALOGUE® studied?

ZEGALOGUE® was studied in a clinical trial program of people with type 1 diabetes.

Two trials were conducted in adults, and a third trial was conducted in children and adolescents aged 6 years to 17 years. In all 3 trials, the results of participants who received ZEGALOGUE® were compared with the results of those who received a placebo following insulin-induced low blood sugar. 

The primary goal in all 3 trials was to measure the time to blood sugar recovery, defined as an increase in blood sugar of at least 
20 mg/dL from the time of administration, without additional intervention.

What are the possible side effects of ZEGALOGUE®?

ZEGALOGUE® may cause serious side effects, including:

  • High blood pressure. ZEGALOGUE® can cause high blood pressure in certain people with tumors in their adrenal glands
  • Low blood sugar. ZEGALOGUE® can cause certain people with tumors in their pancreas called insulimonas to have low blood sugar
  • Serious allergic reaction. Call your health care provider or get medical help right away if you have a serious allergic reaction, including rash, difficulty breathing, or low blood pressure (hypotension)
What are the most common side effects of ZEGALOGUE®?

In clinical trials, the most common side effects of ZEGALOGUE® in adults were nausea, vomiting, headache, diarrhea, and injection-site pain. In clinical trials, the most common side effects of ZEGALOGUE® in children and adolescents were nausea, vomiting, headache, and injection-site pain. 

These are not all of the possible side effects of ZEGALOGUE®. Call your doctor for medical advice about side effects.

When do I need ZEGALOGUE®?

When you experience very low blood sugar and need help from others, those close to you should administer ZEGALOGUE®. See more useful guidance on how to be prepared for very low blood sugar with ZEGALOGUE® here.

Can I travel with ZEGALOGUE®?

Yes. Keep in mind, once removed from refrigeration, ZEGALOGUE® can be stored at room temperature (68 °F to 77 °F) for up to 12 months, or until the original expiration date on the label, whichever comes first. Do not return to the refrigerator after storing at room temperature.


Store in the provided protective case and protect from light. See full storage instructions here.

About Cost and Coverage

Does ZEGALOGUE® have a savings offer?

If you have commercial insurance, such as insurance you receive through an employer, depending on your insurance coverage and out-of-pocket responsibility, you may pay $35 or $99 for each one-pack prescription for up to 48 months from date of Savings Offer activation.*

Call 1-833-992-3301 or visit to get a Savings Offer.

Are you a health care professional?

The information in this section of the website is intended for US health care professionals only.


Are you ready to leave?

You are now leaving

By clicking the “Continue” button below, you will be taken to a website that may contain links or references to other websites in which our privacy policy may not apply. We encourage you to read the privacy policy of every website you visit. By clicking the “No thanks” button below, you will be taken to the page you were on previously.